Caspase 6 anticorps (N-Term)

N° du produit ABIN5518670

Cet anticorps anti-Caspase 6 est un anticorps Lapin Polyclonal détectant Caspase 6 dans WB et IHC. Adapté pour Souris et Rat.

Aperçu rapide pour Caspase 6 anticorps (N-Term) (ABIN5518670)

Antigène: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Caspase 6 anticorps

Épitope: AA 7-27, N-Term

Fonction: Anti-Caspase-6(P18)/CASP6 Antibody Picoband®

Séquence: FYRSREVLDP AEQYKMDHKR R

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Caspase-6 (P18)/CASP6 Antibody (ABIN5518670). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6(P18), different from the related mouse sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Mouse, Rat
1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Caspase 6

Antigène: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Autre désignation: CASP6

Sujet:

Synonyms: Caspase-6,CASP-6,3.4.22.59,Apoptotic protease Mch-2,Caspase-6 subunit p18,Caspase-6 subunit p11,Casp6,Mch2,

Background: Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.

Poids moléculaire: 35 kDa

UniProt: O35397

Pathways: Apoptose, Caspase Cascade in Apoptosis