Angiopoietin 2 anticorps (AA 180-283)

N° du produit ABIN5518732

3+ publications sont disponibles pour ce produit. L’anticorps anti-Angiopoietin 2 Polyclonal produit chez le Lapin a été validé pour WB, IHC et ELISA. Il convient pour la détection de Angiopoietin 2 dans des échantillons provenant de Humain. }

Aperçu rapide pour Angiopoietin 2 anticorps (AA 180-283) (ABIN5518732)

Antigène: Angiopoietin 2 (ANGPT2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiopoietin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Angiopoietin 2 anticorps

Épitope: AA 180-283

Fonction: Anti-Angiopoietin-2/ANGPT2 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Angiopoietin-2/ANGPT2 Antibody (ABIN5518732). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Angiopoietin-2 recombinant protein (Position: E180-D283). Human Angiopoietin-2 shares 75% and 77.9% amino acid (aa) sequence identity with mouse and rat Angiopoietin-2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
ELISA(Cap) , 1-5 μg/mL, Human, -

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-Angiopoietin 2 (ABIN5518732)

Huang, Pan, Yu, Guo, Wang, Zhang, Wang, Gao: "Benefical therapeutic effect of Chinese Herbal Xinji'erkang formula on hypertension-induced renal injury in the 2-kidney-1-clip hypertensive rats." dans: African journal of traditional, complementary, and alternative medicines : AJTCAM, Vol. 11, Issue 5, pp. 16-27, (2015) (PubMed).

Bai, Li, Tian, Zhou: "Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes." dans: PLoS ONE, Vol. 9, Issue 4, pp. e96117, (2014) (PubMed).

Li, Fan, Song, Zhang, Chen, Li, Mi, Ma, Song, Tao, Li: "Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma." dans: PLoS ONE, Vol. 8, Issue 9, pp. e75388, (2013) (PubMed).

Détails sur Angiopoietin 2

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: ANGPT2

Sujet:

Synonyms: Angiopoietin-2,ANG-2,ANGPT2,

Tissue Specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Background: ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

Poids moléculaire: 70 kDa

ID gène: 285

UniProt: O15123

Pathways: Signalisation RTK