KCTD11 anticorps (AA 21-53)

N° du produit ABIN5531951

Détail du produit anti-KCTD11 anticorps

Antigène: KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))

Épitope: AA 21-53

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCTD11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.

Isotype: Ig Fraction

Information d'application

Indications d'application: For IHC-P starting dilution is: 1:25

For WB starting dilution is: 1:1000-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur KCTD11

Antigène: KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))

Autre désignation: KCTD11 (KCTD11 Produits)

Synonymes: anticorps KCTD11, anticorps AF465352, anticorps Ren, anticorps C17orf36, anticorps KCASH1, anticorps REN, anticorps REN/KCTD11, anticorps potassium channel tetramerization domain containing 11, anticorps potassium channel tetramerisation domain containing 11, anticorps KCTD11, anticorps Kctd11

Sujet: Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

Poids moléculaire: 26 kDa

ID gène: 147040

UniProt: Q693B1

Pathways: Signalisation Hedgehog