GDF15 anticorps (N-Term)

N° du produit ABIN5540380

Cet anticorps anti-GDF15 est un anticorps Souris Monoclonal détectant GDF15 dans FACS et EIA. Adapté pour Humain.

Aperçu rapide pour GDF15 anticorps (N-Term) (ABIN5540380)

Antigène: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GDF15 est non-conjugé

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: ME-6D10

Détail du produit anti-GDF15 anticorps

Épitope: AA 30-194, N-Term

Specificité: Recognizes Human Macrophage Inhibitory Cytokine-1 (MIC-1). Other species not tested.

Purification: Affinity Chromatography on Protein G

Immunogène: Genetic immunisation with cDNA encoding amino acids 30-194 (N-term) of MIC-1 proprotein.

Isotype: IgG1

Information d'application

Indications d'application: Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow Cytometry: 1.2 μg/10 6 cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2 without preservatives

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur GDF15

Antigène: GDF15 (Growth Differentiation Factor 15 (GDF15))

Autre désignation: gdf15

Sujet: Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance (1). MIC-1 is synthesized as a 62- kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25- kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines (1,2). MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours (3).

UniProt: Q99988

Pathways: SARS-CoV-2 Protein Interactome