DIABLO anticorps (AA 56-239)

N° du produit ABIN5541224

Cet anticorps Souris Monoclonal détecte spécifiquement DIABLO dans WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour DIABLO anticorps (AA 56-239) (ABIN5541224)

Antigène: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DIABLO est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT19F2

Détail du produit anti-DIABLO anticorps

Épitope: AA 56-239

Purification: Protein-A affinity chromatography

Immunogène: Recombinant human SMAC/Diablo (56-239aa) purified from E. coli

Isotype: IgG2a

Information d'application

Indications d'application: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.Recommended starting dilution is 1:3000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur DIABLO

Antigène: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Autre désignation: diablo,smac

Sujet: SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes

UniProt: Q9NR28

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity