MICA anticorps

N° du produit ABIN5542050

L’anticorps Souris Monoclonal anti-MICA a été validé pour FACS et EIA. Il convient pour détecter MICA dans des échantillons de Humain.

Aperçu rapide pour MICA anticorps (ABIN5542050)

Antigène: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MICA est non-conjugé

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: B-Z26

Détail du produit anti-MICA anticorps

Specificité: This antibody recognizes both natural and recombinant MICA. Species: Human.

Purification: Ion Exchange Chromatography

Immunogène: Recombinant Human MICA

Isotype: IgG2a

Information d'application

Indications d'application: ELISA. Flow Cytometry: Use 10 μL to label 10 6 cells or 100 μL of whole blood.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS Preservatives: 0.09 % Sodium Azide Stabilizers: 1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MICA

Antigène: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Autre désignation: mica

Sujet: The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system. MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.

UniProt: Q29983

Pathways: Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response