Cyclin D1 anticorps

N° du produit ABIN5557293

Cet anticorps Lapin Monoclonal détecte spécifiquement Cyclin D1 dans WB, IHC (p) et IF (cc). Il présente une réactivité envers Humain.

Aperçu rapide pour Cyclin D1 anticorps (ABIN5557293)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 2H4

Détail du produit anti-Cyclin D1 anticorps

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Recombinant human Cyclin D1 protein, around C-terminal 150aa.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: Cyclin D1

Sujet:

Synonyms: Cyclin D1 phospho T286, p-Cyclin D1 phospho T286, AI327039, B cell ccl/lymphoma 1, B cell leukemia 1, B-cell CLL/lymphoma 1, B-cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL1, BCL1 oncogene, CCND 1, CCND1, CCND1 protein, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, included, cD1, Cyclin D1, Cyl-1, D11S287E, G1/S specic cyclin D1, MGC137744, Parathyroid adenomatosis 1, PRAD1, PRAD1 oncogene, U21B31, CCND1_HUMAN.

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].

ID gène: 595

UniProt: P24385

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling