Recombinant CDK6 anticorps

N° du produit ABIN5557433

Cet anticorps anti-CDK6 Monoclonal Lapin (ABIN5557433) détecte spécifiquement CDK6 dans WB, IF, FACS, IHC (p), ICC et IHC (fro). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant CDK6 anticorps (ABIN5557433)

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-CDK6 anticorps

Fonction: Cdk6 Recombinant Antibody

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Recombinant human Cdk6 protein, full length.

Isotype: IgG

Information d'application

Indications d'application: WB(1 μg/Test), IHC-P(1:200-400), IHC-F(1:100-500), IF(), Flow-Cyt(1 μg/Test), ICC/IF(1:50-100)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CDK6

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Autre désignation: Cdk6

Sujet:

Synonyms: MCPH12, PLSTIRE, Cyclin-dependent kinase 6, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, CDK6, CDKN6

Background: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

ID gène: 1021

UniProt: Q00534

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases