CDK6 anticorps (N-Term)
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- Antigène Voir toutes CDK6 Anticorps
- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CDK6 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Specificité
- CDK6 Antibody detects endogenous levels of total CDK6.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human CDK6, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CDK6 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." dans: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).
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miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." dans: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).
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- Antigène
- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
- Autre désignation
- CDK6 (CDK6 Produits)
- Synonymes
- anticorps CDK6, anticorps PLSTIRE, anticorps 5830411I20, anticorps AI504062, anticorps Crk2, anticorps cyclin dependent kinase 6, anticorps cyclin-dependent kinase 6, anticorps CDK6, anticorps Cdk6
- Sujet
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Description: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Gene: CDK6
- Poids moléculaire
- 36kDa
- ID gène
- 1021
- UniProt
- Q00534
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases
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