Recombinant Angiopoietin 2 anticorps

N° du produit ABIN5564223

Détail du produit anti-Angiopoietin 2 anticorps

Antigène: Angiopoietin 2 (ANGPT2)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Angiopoietin 2 est non-conjugé

Application: ELISA, Functional Studies (Func)

Specificité: Recognizes human and mouse angiopoietin-2.

Réactivité croisée: Humain, Souris

Réactivité croisée (Details): Does not detect human angiopoietin-1.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human angiopoietin-2.

Clone: Angy-2-1

Isotype: IgG2b

Information d'application

Commentaires:

anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse lgG2b Fc domain.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur Angiopoietin 2

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: Angiopoietin-2 (ANGPT2 Produits)

Synonymes: anticorps AGPT2, anticorps ANG2, anticorps Agpt2, anticorps Ang-2, anticorps Ang2, anticorps ang2, anticorps angpt2, anticorps ANGIOPOIETIN-2, anticorps ANG-2, anticorps ANGPT2, anticorps Angrp, anticorps Rnase5b, anticorps ANG3, anticorps C11orf2, anticorps C11orf3, anticorps FFR, anticorps angiopoietin 2, anticorps angiopoietin 2b, anticorps angiogenin, ribonuclease A family, member 2, anticorps VPS51, GARP complex subunit, anticorps ANGPT2, anticorps Angpt2, anticorps angpt2b, anticorps Ang2, anticorps VPS51

Sujet: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.

UniProt: O15123

Pathways: Signalisation RTK