APAF1 anticorps (AA 1138-1237)

N° du produit ABIN5611196

Cet anticorps Souris Monoclonal détecte spécifiquement APAF1 dans ELISA, ICC et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour APAF1 anticorps (AA 1138-1237) (ABIN5611196)

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APAF1 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 2H9A1

Détail du produit anti-APAF1 anticorps

Épitope: AA 1138-1237

Fonction: APAF1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human APAF1 (AA: 1138-1237) expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100 - 1/500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur APAF1

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Autre désignation: APAF1

Sujet: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Poids moléculaire: 141.8 kDa

ID gène: 317

Pathways: Signalisation p53, Apoptose, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity