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APAF1 anticorps (AA 1138-1237)

APAF1 Reactivité: Humain WB, ELISA, IHC, ICC, FACS, Neut Hôte: Souris Monoclonal 2H9A1 unconjugated
N° du produit ABIN5611196
  • Antigène Voir toutes APAF1 Anticorps
    APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
    Épitope
    • 16
    • 15
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1138-1237
    Reactivité
    • 84
    • 51
    • 50
    • 15
    • 1
    Humain
    Hôte
    • 71
    • 8
    • 7
    • 1
    Souris
    Clonalité
    • 64
    • 23
    Monoclonal
    Conjugué
    • 43
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp APAF1 est non-conjugé
    Application
    • 52
    • 27
    • 26
    • 25
    • 21
    • 14
    • 13
    • 13
    • 12
    • 12
    • 9
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human APAF1 (AA: 1138-1237) expressed in E. coli.
    Clone
    2H9A1
    Isotype
    IgG2b
    Top Product
    Discover our top product APAF1 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:100 - 1:500, FCM: 1:200 - 1:400, IHC: N/A
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Antigène
    APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
    Autre désignation
    APAF1 (APAF1 Produits)
    Synonymes
    anticorps APAF1, anticorps ARK, anticorps Apaf-1, anticorps Apaf1, anticorps CG6829, anticorps D-Apaf-1, anticorps DARK, anticorps Dapaf-1, anticorps Dapaf-1/HAC-1, anticorps Dark, anticorps Dark/Apaf-I, anticorps Dark/Dapaf-1/HAC1, anticorps Dark/Hac-1/dApaf-1, anticorps Dark/Hac-1/dApaf1, anticorps Dmel\\CG6829, anticorps Hac-1, anticorps Hac-1/Dark, anticorps Hac1, anticorps T1, anticorps anon-53Fa, anticorps apaf-1, anticorps apaf1, anticorps arc, anticorps ark, anticorps dAPAF-1, anticorps dApaf-1, anticorps dApaf-1/DARK/HAC-1, anticorps dApaf1, anticorps dArk, anticorps dapaf, anticorps dapaf-1, anticorps dapaf-1L, anticorps dapaf-1S, anticorps dark, anticorps dark/dapaf-1/hac-1, anticorps dark/hac-1/dapaf-1, anticorps hac-1, anticorps hac1, anticorps l(2)SH0173, anticorps APAF-1, anticorps CED4, anticorps 6230400I06Rik, anticorps Apaf1l, anticorps fog, anticorps mKIAA0413, anticorps zgc:136543, anticorps Death-associated APAF1-related killer, anticorps apoptotic peptidase activating factor 1 L homeolog, anticorps apoptotic peptidase activating factor 1, anticorps Dark, anticorps apaf1.L, anticorps apaf1, anticorps APAF1, anticorps Apaf1
    Sujet

    Description: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

    Aliases: CED4, APAF-1

    Poids moléculaire
    141.8 kDa
    ID gène
    317
    HGNC
    317
    Pathways
    Signalisation p53, Apoptose, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity
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