Nischarin anticorps (C-Term)

N° du produit ABIN5672022

Cet anticorps anti-Nischarin est un anticorps Lapin Polyclonal détectant Nischarin dans WB. Adapté pour Humain.

Aperçu rapide pour Nischarin anticorps (C-Term) (ABIN5672022)

Antigène: Nischarin (NISCH)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nischarin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Nischarin anticorps

Épitope: C-Term

Séquence: LLDEDCVHYP LPEFAKEPPQ RDRYRLDDGR RVRDLDRVLM GYQTYPQALT

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human NISCH

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Nischarin

Antigène: Nischarin (NISCH)

Autre désignation: NISCH

Sujet: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.

Alias Symbols: I-1, IR1, IRAS, hIRAS

Protein Size: 993

ID gène: 11188

NCBI Accession: NM_001276293, NP_001263222