KPNA4 anticorps (AA 1-100) (Biotin)

N° du produit ABIN5675544

Cet anticorps Lapin Polyclonal détecte spécifiquement KPNA4 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris.

Aperçu rapide pour KPNA4 anticorps (AA 1-100) (Biotin) (ABIN5675544)

Antigène: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA4 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-KPNA4 anticorps (Biotin)

Épitope: AA 1-100

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KPNA4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur KPNA4

Antigène: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Autre désignation: KPNA4

Sujet:

Synonyms: Importin subunit alpha-3, KPNA4, Importin alpha Q1, Qip1, Karyopherin subunit alpha-4, QIP1

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS.

ID gène: 3840

UniProt: O00629

Pathways: Protein targeting to Nucleus