GRAP2 anticorps

N° du produit ABIN567995

L’anticorps anti-GRAP2 Monoclonal Souris est utilisé pour la détection de GRAP2 dans des échantillons de Humain. Il a été validé pour WB, IP et FACS.

Aperçu rapide pour GRAP2 anticorps (ABIN567995)

Antigène: GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRAP2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: UW40

Détail du produit anti-GRAP2 anticorps

Specificité: This antibody detects recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein-A affinity chromatography

Immunogène: GST-fusion human GRAP2/GADS protein

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur GRAP2

Antigène: GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))

Autre désignation: GRAP2

Sujet: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.Synonyms: Adapter protein GRID, GADS, GRB-2-like protein, GRB2-related adapter protein 2, GRB2L, GRBLG, GRBX, GRID, Grf-40, Grf40 adapter protein, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, SH3-SH2-SH3 adapter Mona

ID gène: 9402

NCBI Accession: NP_004801

UniProt: O75791

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway