Choline Acetyltransferase anticorps

N° du produit ABIN5687549

Cité dans 1 publication. Cet anticorps anti-Choline Acetyltransferase Polyclonal Chèvre (ABIN5687549) détecte spécifiquement Choline Acetyltransferase dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Poulet et Chévre.

Aperçu rapide pour Choline Acetyltransferase anticorps (ABIN5687549)

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reactivité: Humain, Souris, Rat, Poulet, Chévre

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Choline Acetyltransferase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Choline Acetyltransferase anticorps

Specificité: Specific for the ~ 70k choline acetyltransferase protein

Purification: Affinity Purified

Immunogène: Native choline acetyltransferase purified from human placenta.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: Choline Acetyltransferase antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Références pour anticorps anti-Choline Acetyltransferase (ABIN5687549)

Gonzales, Pare, Wichmann, Smith: "GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen." dans: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2502-22, (2014) (PubMed).

Détails sur Choline Acetyltransferase

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Autre désignation: Choline Acetyltransferase

Sujet: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).

Poids moléculaire: 70 kDa

ID gène: 1103

UniProt: P28329

Pathways: Skeletal Muscle Fiber Development