Connexin 43/GJA1 anticorps (pSer368)

N° du produit ABIN5688898

L’anticorps Lapin Polyclonal anti-Connexin 43/GJA1 a été validé pour WB. Il convient pour détecter Connexin 43/GJA1 dans des échantillons de Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio) et Chévre.

Aperçu rapide pour Connexin 43/GJA1 anticorps (pSer368) (ABIN5688898)

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio), Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Connexin 43/GJA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Connexin 43/GJA1 anticorps

Épitope: pSer368

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin 43.

Information d'application

Indications d'application: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, guinea pig, human, mouse and zebra fish based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: Connexin 43 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Détails sur Connexin 43/GJA1

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Autre désignation: Connexin 43

Sujet: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin 43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin 43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin 43 that results in a decrease in gap junction permeability (Bao et al., 2004b).

Poids moléculaire: 43 kDa

ID gène: 24392

UniProt: P08050

Pathways: Signalisation MAPK, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization