IGF1 anticorps (pTyr1280)

N° du produit ABIN5689215

Détail du produit anti-IGF1 anticorps

Antigène: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Épitope: pTyr1280

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGF1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: IGF-1R (Phospho-Tyr1280) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y (p) -Y-S) derived from Human IGF-1R.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur IGF1

Antigène: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Autre désignation: IGF 1 (IGF1 Produits)

Synonymes: anticorps IGF-I, anticorps IGF1A, anticorps IGFI, anticorps C730016P09Rik, anticorps Igf-1, anticorps Igf-I, anticorps Npt2B, anticorps IGF-1, anticorps IGFIA, anticorps IGF-IB, anticorps igf1, anticorps IGF-1L, anticorps IGF-1a, anticorps IGF1, anticorps igf-1, anticorps igf1-A, anticorps igf1.S, anticorps xigf1, anticorps insulin like growth factor 1, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I, anticorps insulin like growth factor 1 L homeolog, anticorps IGF1, anticorps Igf1, anticorps LOC100136741, anticorps igf1, anticorps LOC678666, anticorps igf1.L, anticorps LOC104911603

Sujet: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Poids moléculaire: 200, 95 kDa

ID gène: 3480

NCBI Accession: NP_000866

UniProt: P08069

Pathways: Signalisation RTK, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation