Cortactin anticorps (AA 419-423)

N° du produit ABIN5689260

Cet anticorps Lapin Polyclonal détecte spécifiquement Cortactin dans IHC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Cortactin anticorps (AA 419-423) (ABIN5689260)

Antigène: Cortactin (CTTN)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cortactin est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Cortactin anticorps

Épitope: AA 419-423

Specificité: This antibody detects endogenous level of total Cortactin protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Cortactin (Ab-421) antibody was raised against a peptide sequence around aa.419~423 (P-I-Y-E-D) derived from Human CORTACTIN.

Information d'application

Indications d'application: Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur Cortactin

Antigène: Cortactin (CTTN)

Autre désignation: Cortactin

Sujet: Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Poids moléculaire: 85 kDa

ID gène: 2017

NCBI Accession: NP_005222

UniProt: Q14247

Pathways: Signalisation MAPK