FOXA2 anticorps (AA 435-439)

N° du produit ABIN5689275

Cet anticorps Lapin Polyclonal détecte spécifiquement FOXA2 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour FOXA2 anticorps (AA 435-439) (ABIN5689275)

Antigène: FOXA2 (Forkhead Box A2 (FOXA2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXA2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FOXA2 anticorps

Épitope: AA 435-439

Specificité: This antibody detects endogenous level of total FoxA2 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: FoxA2 (HNF3beta) antibody was raised against a peptide sequence around aa.435~439 ( A-S-P-L-A) derived from Human FoxA2 (HNF3β,).

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur FOXA2

Antigène: FOXA2 (Forkhead Box A2 (FOXA2))

Autre désignation: FoxA2

Sujet: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs, FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Poids moléculaire: 50 kDa

ID gène: 3170

NCBI Accession: NP_068556

UniProt: Q9Y261

Pathways: Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process