SNCA anticorps (AA 123-131)

N° du produit ABIN5689371

Cet anticorps Lapin Polyclonal détecte spécifiquement SNCA dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour SNCA anticorps (AA 123-131) (ABIN5689371)

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SNCA anticorps

Épitope: AA 123-131

Specificité: This antibody detects endogenous level of total Synuclein protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: a-Synuclein (Ab-125) antibody was raised against a peptide sequence around aa.123~127 (E-A-Y-E-M ) derived from Human α,-Synuclein.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: a Synuclein

Sujet: SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95 % sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

Poids moléculaire: 18 kDa

ID gène: 6622

NCBI Accession: NP_000336

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity