SNCA anticorps (AA 134-138)

N° du produit ABIN5689374

Cet anticorps Lapin Polyclonal détecte spécifiquement SNCA dans WB et IF. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour SNCA anticorps (AA 134-138) (ABIN5689374)

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-SNCA anticorps

Épitope: AA 134-138

Specificité: This antibody detects endogenous level of total α,-Synuclein protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: a-Synuclein (Ab-136) antibody was raised against a peptide sequence around aa. 134~138 (Q-D-Y-E-P) derived from Mouse α,-Synuclein.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: a Synuclein

Sujet: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Poids moléculaire: 18 kDa

ID gène: 20617

NCBI Accession: NP_001035916

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity