TET1 anticorps (AA 2030-2080)

N° du produit ABIN5690283

Cet anticorps Lapin Polyclonal détecte spécifiquement TET1 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour TET1 anticorps (AA 2030-2080) (ABIN5690283)

Antigène: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TET1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TET1 anticorps

Épitope: AA 2030-2080

Specificité: TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.

Purification: TET1 antibody is affinity chromatography purified via peptide column.

Immunogène: TET1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET1.

The immunogen is located within amino acids 2030 - 2080 of TET1.

Isotype: IgG

Information d'application

Indications d'application: TET1 antibody can be used for detection of TET1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TET1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: TET1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur TET1

Antigène: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Autre désignation: TET1

Sujet: TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t(10,11)(q22,q23) (1). It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2). TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3). Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4).

Poids moléculaire: Predicted: 235 kDa

Observed: 240 kDa

ID gène: 80312

NCBI Accession: NP_085128

UniProt: Q8NFU7

Pathways: Stem Cell Maintenance, L'effet Warburg