+49 (0)241 95 163 153
+49 (0)241 95 163 155

TET1 anticorps (C-Term)

TET1 Reactivité: Humain, Souris WB, IHC, ChIP, ChIP-seq Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6972860
  • Antigène Voir toutes TET1 Anticorps
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 15
    • 12
    • 4
    Humain, Souris
    • 14
    • 7
    • 1
    • 13
    • 9
    • 18
    • 2
    • 1
    • 1
    Cet anticorp TET1 est non-conjugé
    • 16
    • 9
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)
    Attributs du produit
    Tet1 (Ten-Eleven Translocation-1, methylcytosine dioxygenase) is a protein that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) which can lead to cytosine demethylation by either further oxidation via Tet proteins to 5-formylcytosine (5fC) and 5-carboxycytosine (5caC) or deamination into 5-hydroxymethyluracil (5hmU) and then subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Tet1 preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells, it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Tet1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq, Immunohistochemistry and Western blot, it has been shown to react with Human and Mouse samples.
    Affinity Purified
    This antibody was raised against a peptide within the C-terminal region of mouse Tet1.
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    Discover our top product TET1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    -20 °C
    Stockage commentaire
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Antigène
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Autre désignation
    Tet1 (TET1 Produits)
    anticorps CXXC6, anticorps LCX, anticorps bA119F7.1, anticorps 2510010B09Rik, anticorps AA517754, anticorps BB001228, anticorps Cxxc6, anticorps D10Ertd17e, anticorps mKIAA1676, anticorps tet methylcytosine dioxygenase 1, anticorps solute carrier family 25 member 16, anticorps TET1, anticorps Tet1, anticorps SLC25A16
    Poids moléculaire
    215 kDa
    NCBI Accession
    Stem Cell Maintenance, L'effet Warburg
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