TRIP12 anticorps (AA 1930-1980)

N° du produit ABIN5690304

Cet anticorps Lapin Polyclonal détecte spécifiquement TRIP12 dans WB, ELISA, IHC (p) et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TRIP12 anticorps (AA 1930-1980) (ABIN5690304)

Antigène: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIP12 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-TRIP12 anticorps

Épitope: AA 1930-1980

Specificité: TRIP12 antibody is human, mouse and rat reactive. At least four isoforms are known to exist.

Purification: TRIP12 antibody is affinity chromatography purified via peptide column.

Immunogène: TRIP12 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human TRIP12.

The immunogen is located within amino acids 1930 - 1980 of TRIP12.

Isotype: IgG

Information d'application

Indications d'application: TRIP12 antibody can be used for detection of TRIP12 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIP12 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: TRIP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur TRIP12

Antigène: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Autre désignation: TRIP12

Sujet: Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner (1). TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway and also modulates the NEDD8 pathway (2,3). TRIP12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site (4). TRIP12 acts as a key regulator of DNA damage response and the ubiquitin ligase activity of TRIP12 is essential for mouse development (5).

Poids moléculaire: Predicted: 219 kDa

Observed: 220 kDa

ID gène: 9320

NCBI Accession: NP_004229

UniProt: Q14669

Pathways: Nuclear Hormone Receptor Binding