TRIP12 anticorps (AA 1930-1980)

N° du produit ABIN5690304

Détail du produit anti-TRIP12 anticorps

Antigène: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Épitope: AA 1930-1980

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIP12 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: TRIP12 antibody is human, mouse and rat reactive. At least four isoforms are known to exist.

Purification: TRIP12 antibody is affinity chromatography purified via peptide column.

Immunogène: TRIP12 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human TRIP12.

The immunogen is located within amino acids 1930 - 1980 of TRIP12.

Isotype: IgG

Information d'application

Indications d'application: TRIP12 antibody can be used for detection of TRIP12 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIP12 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: TRIP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur TRIP12

Antigène: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Autre désignation: TRIP12 (TRIP12 Produits)

Synonymes: anticorps ULF, anticorps TRIP-12, anticorps 1110036I07Rik, anticorps 6720416K24Rik, anticorps AA410158, anticorps Gtl6, anticorps thyroid hormone receptor interactor 12, anticorps E3 ubiquitin-protein ligase TRIP12, anticorps TRIP12, anticorps CpipJ_CPIJ012812, anticorps PTRG_06487, anticorps LOAG_11488, anticorps LOC100631469, anticorps Trip12

Sujet: Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner (1). TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway and also modulates the NEDD8 pathway (2,3). TRIP12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site (4). TRIP12 acts as a key regulator of DNA damage response and the ubiquitin ligase activity of TRIP12 is essential for mouse development (5).

Poids moléculaire: Predicted: 219 kDa

Observed: 220 kDa

ID gène: 9320

NCBI Accession: NP_004229

UniProt: Q14669

Pathways: Nuclear Hormone Receptor Binding