GLUD1 anticorps

N° du produit ABIN5697821

L’anticorps anti-GLUD1 Polyclonal produit chez le Lapin a été validé pour WB, IHC, IP et ELISA. Il convient pour la détection de GLUD1 dans des échantillons provenant de Humain, Souris et Rat. }

Aperçu rapide pour GLUD1 anticorps (ABIN5697821)

Antigène: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLUD1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA

Détail du produit anti-GLUD1 anticorps

Fonction: GLUD1 antibody

Immunogène: glutamate dehydrogenase 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab03498(GLUD1 antibody) at dilution of 1:3000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur GLUD1

Antigène: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Autre désignation: GLUD1

Sujet:

Synonyms: Glutamate dehydrogenase 1, mitochondrial (GDH 1)|GLUD1|GLUD

Background: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

Poids moléculaire: 45-55 kDa

ID gène: 2746

UniProt: P00367

Pathways: Positive Regulation of Peptide Hormone Secretion, L'effet Warburg