Sonic Hedgehog anticorps (AA 48-197)

N° du produit ABIN5699367

Cet anticorps anti-Sonic Hedgehog est un anticorps Lapin Polyclonal détectant Sonic Hedgehog dans WB, IHC, ELISA, IP et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Sonic Hedgehog anticorps (AA 48-197) (ABIN5699367)

Antigène: Sonic Hedgehog (SHH)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sonic Hedgehog est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-Sonic Hedgehog anticorps

Épitope: AA 48-197

Fonction: SHH antibody

Immunogène:

Immunogen sequence: 48-197aa

Immunogen: sonic hedgehog homolog (Drosophila)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab07847(SHH antibody) at dilution of 1:800

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Sonic Hedgehog

Antigène: Sonic Hedgehog (SHH)

Autre désignation: SHH

Sujet:

Synonyms: Sonic hedgehog protein (SHH)|HHG-1|Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (ShhNC)|Sonic hedgehog protein N-product (ShhN) Alternative names: Shh N-terminal processed signaling domains (ShhNp)|SHH

Background: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

ID gène: 6469

UniProt: Q15465

Pathways: Signalisation Hedgehog, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development