INSIG1 anticorps

N° du produit ABIN5703038

L’anticorps Lapin Polyclonal anti-INSIG1 a été validé pour WB, ELISA, IHC, IF et IP. Il convient pour détecter INSIG1 dans des échantillons de Humain et Souris.

Aperçu rapide pour INSIG1 anticorps (ABIN5703038)

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-INSIG1 anticorps

Fonction: INSIG1 antibody

Immunogène: insulin induced gene 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

A549 cells were subjected to SDS PAGE followed by western blot with FNab04333(INSIG1 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur INSIG1

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Autre désignation: INSIG1

Sujet:

Synonyms: Insulin-induced gene 1 protein (INSIG-1)|INSIG1

Background: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation(ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Poids moléculaire: 28-31, 66-70 kDa

ID gène: 3638

UniProt: O15503

Pathways: ER-Nucleus Signaling