TXK anticorps

N° du produit ABIN5703141

Cet anticorps anti-TXK Polyclonal Lapin (ABIN5703141) détecte spécifiquement TXK dans ELISA, IHC et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TXK anticorps (ABIN5703141)

Antigène: TXK (TXK tyrosine Kinase (TXK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXK est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TXK anticorps

Fonction: TXK antibody

Immunogène: TXK tyrosine kinase

Isotype: IgG

Information d'application

Indications d'application: IF:1:10-1:100,IHC:1:20-1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TXK

Antigène: TXK (TXK tyrosine Kinase (TXK))

Autre désignation: TXK

Sujet:

Synonyms: Tyrosine-protein kinase TXK|Protein-tyrosine kinase 4|Resting lymphocyte kinase|TXK|PTK4|RLK

Background: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells(APC) activate T-cell receptor(TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells(NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1(Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Poids moléculaire: 25kDa,Observed 45kDa

ID gène: 7294

UniProt: P42681

Pathways: Regulation of Leukocyte Mediated Immunity, Hepatitis C