IDE anticorps

N° du produit ABIN5708390

Cet anticorps Lapin Polyclonal détecte spécifiquement IDE dans WB, ELISA, IHC (p) et FACS. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour IDE anticorps (ABIN5708390)

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IDE est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-IDE anticorps

Purification: Antigen affinity purified

Immunogène: A recombinant human protein corresponding to amino acids F485-K756 was used as the immunogen for the IDE antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the IDE antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL, IHC (FFPE): 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells, Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the IDE antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur IDE

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Autre désignation: IDE / Insulin degrading enzyme

Sujet: Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome