Caspase 8 anticorps (AA 1-479)

N° du produit ABIN6137970

Détail du produit anti-Caspase 8 anticorps

Antigène: Caspase 8 (CASP8)

Épitope: AA 1-479

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKGEELCGV MTISDSPREQ DSESQTLDKV YQMKSKPRGY CLIINNHNFA KAREKVPKLH SIRDRNGTHL DAGALTTTFE ELHFEIKPHD DCTVEQIYEI LKIYQLMDHS NMDCFICCIL SHGDKGIIYG TDGQEAPIYE LTSQFTGLKC PSLAGKPKVF FIQACQGDNY QKGIPVETDS EEQPYLEMDL SSPQTRYIPD EADFLLGMAT VNNCVSYRNP AEGTWYIQSL CQSLRERCPR GDDILTILTE VNYEVSNKDD KKNMGKQMPQ PTFTLRKKLV FPSD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-479 of human Caspase-8 (NP_001073593.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-Caspase 8 (ABIN6137970)

Chen, Deng, Gan, Li, Huang, Lu, Wei, Su, Luo, Zou, Hong, Cao, Liu, Chi: "NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma." dans: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 26, (2020) (PubMed).

Song, Ma, Lu, Zhou, Zhao, Ai, Wei, Lin, Wang, Yan, Jiao: "The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis." dans: Experimental cell research, Vol. 382, Issue 1, pp. 111467, (2020) (PubMed).

Kong, Liu, Zhou, Hou, He, Li, Miao, Yang: "Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells." dans: The international journal of biochemistry & cell biology, Vol. 122, pp. 105731, (2020) (PubMed).

Zhao, Zhu, Bu, Zhou, Bai, Guo, Gao, Lu: "Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis." dans: Redox biology, Vol. 29, pp. 101392, (2020) (PubMed).

Zhou, Li, Han, Feng, Liu, Chen, Liu, Zhao, Jin: "Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway." dans: Investigational new drugs, Vol. 38, Issue 1, pp. 50-59, (2020) (PubMed).

Chen, Fang, Chen, Yang, Zhou, Mao, Xia, Jin, Li, You, Wang, Lei, He, Hu: "Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke." dans: Cell death & disease, Vol. 10, Issue 7, pp. 487, (2020) (PubMed).

Hu, Li, Yu, Liu, Wang, Qing, Wang, Wang, Zhu, Xu, Tan, Guo, Hui: "GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis." dans: Free radical biology & medicine, Vol. 145, pp. 237-249, (2020) (PubMed).

Jin, Shi, Liu, Chen, Yang: "Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway." dans: International journal of molecular sciences, Vol. 20, Issue 19, (2020) (PubMed).

Yu, Ye, Li, Zhan, Liu, Yan, Fang, Xie, Zhang, Chen, Ding, Chen: "Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis." dans: Carcinogenesis, Vol. 41, Issue 5, pp. 678-688, (2020) (PubMed).

Liu, Wei, Fang, Li, Li: "Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro." dans: Microbial pathogenesis, Vol. 149, pp. 104315, (2020) (PubMed).

Chen, Wei, Yang, Guo, Guo, Zhou: "Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 143, pp. 111517, (2020) (PubMed).

Yu, Zhu, Wang, Li, Hu, Qing, Wang, Wang, Wang, Xu, Guo, Hui: "LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis." dans: Acta pharmacologica Sinica, (2020) (PubMed).

Chen, Gan, Li, Gu, Liu, Deng, Wang, Hong, Hu, Su, Chi: "NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye." dans: The ocular surface, Vol. 18, Issue 4, pp. 783-794, (2020) (PubMed).

Cheng, Qin, Huang, Zhou, Xiong, Zhao, Zhang, Yu: "Cytokeratin 18 regulates the transcription and alternative splicing of apoptotic‑related genes and pathways in HeLa cells." dans: Oncology reports, Vol. 42, Issue 1, pp. 301-312, (2019) (PubMed).

Zuo, Kong, Wang, Liu, Wang, Wan, Yan, Zhang, Tang, Zhang, Lyu, Li, Shan, Qian, Shen, Yu: "CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain." dans: EMBO molecular medicine, Vol. 10, Issue 3, (2018) (PubMed).

Xu, Li, Jiang, Feng, Wu, Cai, Zhang, Huang, Sealy, Iqbal, Li: "Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell." dans: Frontiers in microbiology, Vol. 9, pp. 653, (2018) (PubMed).

Cai, Lv, Kaldybayeva, Zhamilya, Wu, Wu: "15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo." dans: Frontiers in pharmacology, Vol. 9, pp. 25, (2018) (PubMed).

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: Casp8 (CASP8 Produits)

Synonymes: anticorps casp8-A, anticorps xCaspase-8, anticorps casp8, anticorps CASP8, anticorps CASP-8, anticorps FLICE, anticorps MACH, anticorps Mch5, anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps MCH5, anticorps caspase-8, anticorps zgc:92075, anticorps caspase 8 L homeolog, anticorps death related ced-3/Nedd2-like protein, anticorps caspase 8, anticorps caspase-8, anticorps caspase-8-like, anticorps caspase 8, apoptosis-related cysteine peptidase, anticorps casp8.L, anticorps LOC661095, anticorps CASP8, anticorps LOC5563818, anticorps casp8, anticorps LOC100222284, anticorps Casp8

Sujet: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.,ALPS2B,CAP4,Casp-8,FLICE,MACH,MCH5,Caspase 8,CASP8,Caspase-8,caspase-8,Cancer,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Caspases,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Ubiquitin,Death Receptor Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,Toll-like Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Casp8

Poids moléculaire: 25-32 kDa/45- 61 kDa

ID gène: 841

UniProt: Q14790

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades