ErbB2/Her2 anticorps (C-Term)

N° du produit ABIN6140248

Cet anticorps anti-ErbB2/Her2 est un anticorps Lapin Polyclonal détectant ErbB2/Her2 dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour ErbB2/Her2 anticorps (C-Term) (ABIN6140248)

Highlights:

• High quality ErbB2/Her2 Anticorps primaire for the detection of ErbB2/Her2.
• Reliable product with high standard validation data

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ErbB2/Her2 anticorps

Épitope: C-Term

Séquence: ARPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLTP QGGAAPQPHP PPAFSPAFDN LYYWDQDPPE RGAPPSTFKG TPTAENPEYL GLDVPV

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1160 to the C-terminus of human HER2 / ErbB2 (NP_004439.2).

Isotype: IgG

Informations sur le produit:

What can the ErbB2/Her2 Antibody ABIN6140248 be used for?: This polyclonal ErbB2/Her2 Antibody detects ErbB2/Her2. The ErbB2/Her2 Antibody has been validated for various applications and can be used for the detection of ErbB2/Her2 and derivatives by Western Blotting, Immunohistochemistry.

What validation data is available for this ErbB2/Her2 Antibody?: The Anticorps primaire has currently 6 product images that show its performance in a variety of applications. The product is currently available in 20 μL, 100 μL, 500 μL, 1000 μL quantities. ErbB2/Her2 Antibody for the detection of ErbB2/Her2 and derivatives.

What is the function of ErbB2/Her2?: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: ErbB2

Sujet: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.,ERBB2,CD340,HER-2,HER-2/neu,HER2,MLN 19,NEU,NGL,TKR1,erb-b2 receptor tyrosine kinase 2,HER2/ErbB2,ErbB2,MLN19,Cancer,Tumor immunology,Tumor-associated antigens,Tumor biomarkers,Signal Transduction,Kinase,Tyrosine kinases,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,EGF,Immunology & Inflammation,CD markers,Cardiovascular,Angiogenesis,ErbB2

Poids moléculaire: 62 kDa/70 kDa/97 kDa/134 kDa/136 kDa/137 kDa

ID gène: 2064

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development