HIRA anticorps (AA 250-550)

N° du produit ABIN6141776

Cet anticorps anti-HIRA est un anticorps Lapin Polyclonal détectant HIRA dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour HIRA anticorps (AA 250-550) (ABIN6141776)

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIRA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HIRA anticorps

Épitope: AA 250-550

Séquence: AQIIEREGWK TNMDFVGHRK AVTVVKFNPK IFKKKQKNGS SAKPSCPYCC CAVGSKDRSL SVWLTCLKRP LVVIHELFDK SIMDISWTLN GLGILVCSMD GSVAFLDFSQ DELGDPLSEE EKSRIHQSTY GKSLAIMTEA QLSTAVIENP EMLKYQRRQQ QQQLDQKSAA TREMGSATSV AGVVNGESLE DIRKNLLKKQ VETRTADGRR RITPLCIAQL DTGDFSTAFF NSIPLSGSLA GTMLSSHSSP QLLPLDSSTP NSFGASKPCT EPVVAASARP AGDSVNKDSM NATSTPAALS P

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human HIRA (NP_003316.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HIRA

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Autre désignation: HIRA

Sujet: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.,HIRA,DGCR1,TUP1,TUPLE1,Epigenetics & Nuclear Signaling,Chromatin Remodeling,Cell Biology & Developmental Biology,Stem Cells,Germline Stem Cells,HIRA

Poids moléculaire: 89 kDa/111 kDa

ID gène: 7290

UniProt: P54198

Pathways: Chromatin Binding