LGMN anticorps (AA 18-323)

N° du produit ABIN6143172

Cet anticorps anti-LGMN est un anticorps Lapin Polyclonal détectant LGMN dans WB et IF. Adapté pour Humain.

Aperçu rapide pour LGMN anticorps (AA 18-323) (ABIN6143172)

Antigène: LGMN (Legumain (LGMN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LGMN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-LGMN anticorps

Épitope: AA 18-323

Séquence: VPIDDPEDGG KHWVVIVAGS NGWYNYRHQA DACHAYQIIH RNGIPDEQIV VMMYDDIAYS EDNPTPGIVI NRPNGTDVYQ GVPKDYTGED VTPQNFLAVL RGDAEAVKGI GSGKVLKSGP QDHVFIYFTD HGSTGILVFP NEDLHVKDLN ETIHYMYKHK MYRKMVFYIE ACESGSMMNH LPDNINVYAT TAANPRESSY ACYYDEKRST YLGDWYSVNW MEDSDVEDLT KETLHKQYHL VKSHTNTSHV MQYGNKTIST MKVMQFQGMK RKASSPVPLP PVTHLDLTPS PDVPLTIMKR KLMNTN

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 18-323 of human Legumain (Legumain (LGMN)) (NP_001008530.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur LGMN

Antigène: LGMN (Legumain (LGMN))

Autre désignation: LGMN

Sujet: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.,LGMN,AEP,LGMN1,PRSC1,legumain,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Bone,Ubiquitin,Endocrine & Metabolism,Immunology & Inflammation,LGMN

Poids moléculaire: 42 kDa/49 kDa

ID gène: 5641

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades