IL23A anticorps

N° du produit ABIN614363

Il existe 4+ publications pour ce produit. L’anticorps anti-IL23A Monoclonal Souris est utilisé pour la détection de IL23A dans des échantillons de Humain. Il a été validé pour WB, IP, IHC (p) et IHC (fro).

Aperçu rapide pour IL23A anticorps (ABIN614363)

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL23A est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: HLT2736

Détail du produit anti-IL23A anticorps

Specificité: Human recombinant p40 and p19 with elastin linker. The HLT2736 clone recognizes Human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a Capture antibody in ELISA.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Recombinant protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Références pour anticorps anti-IL23A (ABIN614363)

Botbol, Patel, Macian: "Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation." dans: Autophagy, Vol. 11, Issue 10, pp. 1864-77, (2015) (PubMed).

Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin." dans: The American journal of pathology, Vol. 177, Issue 2, pp. 735-43, (2010) (PubMed).

Katsifis, Rekka, Moutsopoulos, Pillemer, Wahl: "Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis." dans: The American journal of pathology, Vol. 175, Issue 3, pp. 1167-77, (2009) (PubMed).

Gueirard, Ave, Balazuc, Thiberge, Huerre, Milon, Guiso: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." dans: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, (2003) (PubMed).

Détails sur IL23A

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Autre désignation: Interleukin-23 alpha / IL23A

Sujet: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

ID gène: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation