MEPCE anticorps (AA 470-689)

N° du produit ABIN6143737

Cet anticorps anti-MEPCE est un anticorps Lapin Polyclonal détectant MEPCE dans IF. Adapté pour Humain.

Aperçu rapide pour MEPCE anticorps (AA 470-689) (ABIN6143737)

Antigène: MEPCE (Methylphosphate Capping Enzyme (MEPCE))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEPCE est non-conjugé

Application: Immunofluorescence (IF)

Détail du produit anti-MEPCE anticorps

Épitope: AA 470-689

Séquence: MVGLDIDSRL IHSARQNIRH YLSEELRLPP QTLEGDPGAE GEEGTTTVRK RSCFPASLTA SRGPIAAPQV PLDGADTSVF PNNVVFVTGN YVLDRDDLVE AQTPEYDVVL CLSLTKWVHL NWGDEGLKRM FRRIYRHLRP GGILVLEPQP WSSYGKRKTL TETIYKNYYR IQLKPEQFSS YLTSPDVGFS SYELVATPHN TSKGFQRPVY LFHKARSPSH

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2).

Isotype: IgG

Information d'application

Indications d'application: IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MEPCE

Antigène: MEPCE (Methylphosphate Capping Enzyme (MEPCE))

Autre désignation: MEPCE

Sujet: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA, leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC. In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex, interaction with LARP7 within the 7SK RNP complex occluding its catalytic center.,MEPCE,BCDIN3,Epigenetics & Nuclear Signaling,RNA Binding,MEPCE

Poids moléculaire: 24 kDa/74 kDa

ID gène: 56257

UniProt: Q7L2J0

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2