Plakophilin 2 anticorps (Internal Region)

N° du produit ABIN615975

Détail du produit anti-Plakophilin 2 anticorps

Antigène: Plakophilin 2 (PKP2)

Épitope: AA 125-139, Internal Region

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Plakophilin 2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-RGTAQYSSQK SVEER

Specificité: This antibody is expected to recognize both reported isoforms (NP_001005242.2, NP_004563.2).

Réactivité croisée (Details): Species reactivity (expected):Human, Canine (Dog), Cow.
Species reactivity (tested):Mouse and Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_001005242.2, NP_004563.2. Genename: PKP2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Plakophilin 2

Antigène: Plakophilin 2 (PKP2)

Autre désignation: Plakophilin-2 (PKP2 Produits)

Synonymes: anticorps ARVD9, anticorps 1200008D14Rik, anticorps 1200012P04Rik, anticorps AA516617, anticorps Pkp2l, anticorps plakophilin 2, anticorps PKP2, anticorps Pkp2

Sujet: Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.Synonyms: PKP2

ID gène: 5318

NCBI Accession: NP_004563

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2