CD3 anticorps

N° du produit ABIN616760

L’anticorps Souris Monoclonal anti-CD3 a été validé pour FACS, IP, IHC (fro) et Func. Il convient pour détecter CD3 dans des échantillons de Humain et Singe.

Aperçu rapide pour CD3 anticorps (ABIN616760)

Antigène: CD3

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: UCHT1

Détail du produit anti-CD3 anticorps

Specificité: This antibody recognizes the CD3 antigen of the TCR/CD3 complex on mature Human T cells. The UCHT1 antibody reacts with the epsilon chain of the CD3 complex.

Réactivité croisée (Details): Species reactivity (tested):Human, Non-Human Primates.

Purification: Protein-A Affinity Chromatography

Immunogène: Human thymocytes followed by Sezary T cells.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Azide Free phosphate buffered saline (PBS), pH ~7.4 and 0.2 μm filter sterilized

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD3

Antigène: CD3

Autre désignation: CD3

Sujet: CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4

ID gène: 916

NCBI Accession: NP_000724

UniProt: P07766

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway