INPP5D anticorps (AA 959-1188)

N° du produit ABIN6213625

Cet anticorps Lapin Polyclonal détecte spécifiquement INPP5D dans WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour INPP5D anticorps (AA 959-1188) (ABIN6213625)

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-INPP5D anticorps

Épitope: AA 959-1188

Séquence: SPPTPPGQPP ISPKKFLPST ANRGLPPRTQ ESRPSDLGKN AGDTLPQEDL PLTKPEMFEN PLYGSLSSFP KPAPRKDQES PKMPRKEPPP CPEPGILSPS IVLTKAQEAD RGEGPGKQVP APRLRSFTCS SSAEGRAAGG DKSQGKPKTP VSSQAPVPAK RPIKPSRSEI NQQTPPTPTP RPPLPVKSPA VLHLQHSKGR DYRDNTELPH HGKHRPEEGP PGPLGRTAMQ

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 959-1188 of human SHIP1 (NP_005532.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: INPP5D

Sujet: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.,INPP5D,SHIP,SHIP-1,SHIP1,SIP-145,hp51CN,p150Ship,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Lipid Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,INPP5D

Poids moléculaire: 109 kDa/133 kDa

ID gène: 3635

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg