H2AFX anticorps (pSer139)
Aperçu rapide pour H2AFX anticorps (pSer139) (ABIN6241012)
Antigène
Voir toutes H2AFX AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- pSer139
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Immunogène
- Recombinant Protein
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Indications d'application
- WB: 1:2000. ICC: 1:400
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Restrictions
- For Research Use only
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Format
- Liquid
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Stock
- 4 °C,-20 °C
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- H2AFX (H2A Histone Family, Member X (H2AFX))
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Autre désignation
- Histone H2A.X
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Sujet
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
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UniProt
- P16104
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Pathways
- Telomere Maintenance, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
Antigène
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