PTEN anticorps (pTyr176)

N° du produit ABIN6241055

Cet anticorps Lapin Polyclonal détecte spécifiquement PTEN dans DB. Il présente une réactivité envers Humain.

Aperçu rapide pour PTEN anticorps (pTyr176) (ABIN6241055)

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTEN est non-conjugé

Application: Dot Blot (DB)

Clone: RB39742

Détail du produit anti-PTEN anticorps

Épitope: pTyr176

Homologie: M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y176 of human PTEN.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PTEN

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Autre désignation: PTEN

Sujet: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Poids moléculaire: 47166

NCBI Accession: NP_000305

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling