Tuberin anticorps (pThr1462)

N° du produit ABIN6241057

Cité dans 1 publication. Cet anticorps anti-Tuberin Polyclonal Lapin (Clone RB13340) (ABIN6241057) détecte spécifiquement Tuberin dans DB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Tuberin anticorps (pThr1462) (ABIN6241057)

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tuberin est non-conjugé

Application: Dot Blot (DB)

Clone: RB13340

Détail du produit anti-Tuberin anticorps

Épitope: pThr1462

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1462 of human TSC2.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Tuberin (ABIN6241057)

Wu, Storey: "Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels." dans: The Journal of experimental biology, Vol. 215, Issue Pt 10, pp. 1720-7, (2012) (PubMed).

Détails sur Tuberin

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Autre désignation: TSC2

Sujet: Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Poids moléculaire: 200608

NCBI Accession: NP_000539, NP_001070651, NP_001107854

UniProt: P49815

Pathways: Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus