Ubiquitin B anticorps (N-Term)

N° du produit ABIN6242685

L’anticorps Lapin Polyclonal anti-Ubiquitin B a été validé pour WB. Il convient pour détecter Ubiquitin B dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Ubiquitin B anticorps (N-Term) (ABIN6242685)

Antigène: Ubiquitin B (UBB)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubiquitin B est non-conjugé

Application: Western Blotting (WB)

Clone: RB49507

Détail du produit anti-Ubiquitin B anticorps

Épitope: AA 25-57, N-Term

Homologie: B, E, D, Pr, Pig, Sh, C, Hs, Ha, X, Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This UBB(Ubiquitin) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 25-57amino acids from the N-terminal region of human UBB(Ubiquitin).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur Ubiquitin B

Antigène: Ubiquitin B (UBB)

Autre désignation: UBB(Ubiquitin)

Sujet: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Poids moléculaire: 25762

UniProt: P0CG47

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagy, EGFR Downregulation, Ubiquitin Proteasome Pathway