STUB1 anticorps

N° du produit ABIN6242870

Cet anticorps Souris Monoclonal détecte spécifiquement STUB1 dans WB. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour STUB1 anticorps (ABIN6242870)

Antigène: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STUB1 est non-conjugé

Application: Western Blotting (WB)

Clone: 1008CT12-4-1

Détail du produit anti-STUB1 anticorps

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This STUB1 antibody is generated from a mouse immunized with a recombinant protein of human STUB1.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:4000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur STUB1

Antigène: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Autre désignation: STUB1

Sujet: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

Poids moléculaire: 34856

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation