STUB1 anticorps (C-Term)
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- Antigène Voir toutes STUB1 Anticorps
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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Épitope
- AA 203-231, C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp STUB1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Homologie
- C, M
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogène
- This STUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human STUB1.
- Clone
- RB7393
- Isotype
- Ig Fraction
- Top Product
- Discover our top product STUB1 Anticorps primaire
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- Indications d'application
- WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 6 months
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- Antigène
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
- Autre désignation
- CHIP (STUB1) (STUB1 Produits)
- Synonymes
- anticorps CHIP, anticorps HSPABP2, anticorps NY-CO-7, anticorps SDCCAG7, anticorps UBOX1, anticorps 0610033N24Rik, anticorps 2210017D18Rik, anticorps 2310040B03Rik, anticorps AW046544, anticorps Chip, anticorps wu:fc22f04, anticorps zgc:56076, anticorps STUB1, anticorps chip, anticorps ATCHIP, anticorps CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN, anticorps carboxyl terminus of HSC70-interacting protein, anticorps STIP1 homology and U-box containing protein 1, anticorps STIP1 homology and U-Box containing protein 1, anticorps STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog, anticorps STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase, anticorps STIP1 homology and U box-containing protein 1, anticorps carboxyl terminus of HSC70-interacting protein, anticorps STUB1, anticorps Stub1, anticorps stub1, anticorps stub1.L, anticorps LOC100282870, anticorps CHIP
- Sujet
- CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.
- Poids moléculaire
- 34856
- ID gène
- 10273
- NCBI Accession
- NP_005852
- UniProt
- Q9UNE7
- Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
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