IRAK4 anticorps (N-Term)

N° du produit ABIN6243238

Cité dans 1 publication. Cet anticorps anti-IRAK4 Polyclonal Lapin (Clone RB2347) (ABIN6243238) détecte spécifiquement IRAK4 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IRAK4 anticorps (N-Term) (ABIN6243238)

Antigène: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2347

Détail du produit anti-IRAK4 anticorps

Épitope: AA 5-36, N-Term

Homologie: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This IRAK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-36 amino acids from the N-terminal region of human IRAK4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-IRAK4 (ABIN6243238)

Park, Kim, Yi: "Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6316-27, (2009) (PubMed).

Détails sur IRAK4

Antigène: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Autre désignation: IRAK4

Sujet: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.

Poids moléculaire: 51530

NCBI Accession: NP_001107654, NP_001138728, NP_001138729, NP_001138730, NP_057207

UniProt: Q9NWZ3

Pathways: Signalisation NF-kappaB, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades