H2AFX anticorps (Ser139)
Aperçu rapide pour H2AFX anticorps (Ser139) (ABIN6243686)
Antigène
Voir toutes H2AFX AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
-
-
Épitope
- AA 134-163, Ser139
-
Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
Immunogène
- This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from human.
-
Isotype
- IgG
-
-
-
-
Indications d'application
- WB: 1:1000
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
Agent conservateur
- Sodium azide
-
Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Stock
- 4 °C,-20 °C
-
Date de péremption
- 6 months
-
-
- H2AFX (H2A Histone Family, Member X (H2AFX))
-
Autre désignation
- Histone H2A.X
-
Sujet
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
-
Poids moléculaire
- 15145
-
UniProt
- P16104
-
Pathways
- Telomere Maintenance, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
Antigène
-