SIX Homeobox 1 anticorps (AA 69-102)

N° du produit ABIN6244222

Cet anticorps anti-SIX Homeobox 1 est un anticorps Lapin Polyclonal détectant SIX Homeobox 1 dans WB. Adapté pour Humain et Souris.

Aperçu rapide pour SIX Homeobox 1 anticorps (AA 69-102) (ABIN6244222)

Antigène: SIX Homeobox 1 (SIX1)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIX Homeobox 1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB53311

Détail du produit anti-SIX Homeobox 1 anticorps

Épitope: AA 69-102

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SIX1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 69-102 amino acids from the Central region of human SIX1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SIX Homeobox 1

Antigène: SIX Homeobox 1 (SIX1)

Autre désignation: SIX1

Sujet: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

Poids moléculaire: 32210

UniProt: Q15475

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development