JUP anticorps

N° du produit ABIN6252060

Cet anticorps Souris Monoclonal détecte spécifiquement JUP dans WB, IF et IP. Il présente une réactivité envers Humain, Souris, Rat, Poulet, Boeuf (Vache), Chien et Cat.

Aperçu rapide pour JUP anticorps (ABIN6252060)

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain, Souris, Rat, Poulet, Boeuf (Vache), Chien, Cat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 15F11

Détail du produit anti-JUP anticorps

Purification: Protein G affinity chromatography

Immunogène: Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunofluorescence: 1-2 μg/mL

WB: 0.5-1 μg/mL

Immunoprecipitation: suitable

The stated application concentrations are suggested starting amounts. Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Gamma Catenin

Sujet: Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]

ID gène: 3728

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location