Caspase 3 anticorps (pSer150)

N° du produit ABIN6254994

L’anticorps Lapin Polyclonal anti-Caspase 3 a été validé pour WB, IHC, ELISA, ICC et IF. Il convient pour détecter Caspase 3 dans des échantillons de Humain, Souris et Rat. Il y a 1 publication disponible.

Aperçu rapide pour Caspase 3 anticorps (pSer150) (ABIN6254994)

Antigène: Caspase 3 (CASP3)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-Caspase 3 anticorps

Épitope: pSer150

Specificité: Phospho-Caspase 3 (Ser150) Antibody detects endogenous levels of Caspase 3 only when phosphorylated at Serine 150.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human Caspase 3 around the phosphorylation site of Ser150.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-Caspase 3 (ABIN6254994)

Cui, Lin, Shi, Pan: "Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway." dans: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 277-284, (2017) (PubMed).

Détails sur Caspase 3

Antigène: Caspase 3 (CASP3)

Autre désignation: CASP3

Sujet:

Description: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Gene: CASP3

Poids moléculaire: 34kDa

ID gène: 836

UniProt: P42574

Pathways: Apoptose, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation